Positive regulation of axonogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1B, MFAP5, and BAG2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of axonogenesis activity versus MAP1B in LSCC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+2.187	+0.836	<.001	<.001	3	8
LSCC	MFAP5 →	+1.312	+0.672	<.001	<.001	3	6
CCRCC	BAG2 →	+0.780	+0.579	<.001	.001	3	5
BRCA	BEND6 →	+0.548	+0.538	<.001	<.001	3	5
LSCC	UCHL1 →	+2.220	+0.692	<.001	<.001	3	5
LSCC	FZD7 →	+1.269	+0.590	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050772 vs MAP1B — LSCC

Explore this scatter interactively →