Positive regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINS1, KLHDC3, and ARFGAP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LINS1 grouped by Positive regulation of axonogenesis-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LINS1 →	+0.735	+1.062	<.001	.001	3	5
BLOOD_Leukemia	KLHDC3 →	+0.634	+1.183	<.001	<.001	3	4
OVARY	ARFGAP3 →	-0.533	-0.802	.004	.002	3	4
KIDNEY	MCM2 →	+1.182	+1.150	.008	.003	1	5
LUNG_NSCLC_LUAD	MRPL46 →	+0.452	+0.512	.005	.006	3	3
STOMACH	GALE →	-1.040	-0.282	.005	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LINS1 by Positive regulation of axonogenesis activity — OVARY

Explore this box plot interactively →