Positive regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of axonogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADSL, HDAC2, and AGTR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADSL grouped by Positive regulation of axonogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADSL →	-0.252	-0.072	.004	.005	3	5
BONE	HDAC2 →	+0.325	+0.216	.006	.006	3	5
LARGE_INTESTINE	AGTR2 →	-0.110	-0.072	.009	.005	3	5
LUNG_NSCLC_LUAD	CAPN11 →	-0.134	-0.064	.001	.008	3	4
LUNG_NSCLC_LUAD	SOHLH1 →	+0.158	+0.080	.002	<.001	3	4
BLOOD_Myeloma	ZNF771 →	-0.208	-0.090	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADSL by Positive regulation of axonogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →