Positive regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are REEP3, PFKM, and TSPAN5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of axonogenesis activity versus REEP3 in LUNG_NSCLC_LUAD (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	REEP3 →	+0.890	+0.240	<.001	<.001	3	5
STOMACH	PFKM →	-1.678	-0.261	.002	.001	3	5
SKIN	TSPAN5 →	+2.616	+0.286	<.001	<.001	3	5
LIVER	NOP56 →	-0.987	-0.285	.007	.002	3	5
BONE	PDE4D →	-2.315	-0.336	.009	<.001	3	4
PANCREAS	DDX21 →	-0.899	-0.306	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050772 vs REEP3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →