Negative regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3E, TERF2, and TAF4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3E grouped by Negative regulation of axonogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	POLR3E →	+0.690	+0.270	.002	.004	3	4
KIDNEY	TERF2 →	+0.568	+0.873	.006	.009	3	4
KIDNEY	TAF4B →	+1.135	+1.524	<.001	<.001	3	4
LIVER	CD151 →	-1.435	-1.545	.001	<.001	3	4
URINARY_TRACT	OAF →	-1.645	-1.581	<.001	<.001	3	4
LARGE_INTESTINE	DCLRE1B →	+0.500	+0.817	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3E by Negative regulation of axonogenesis activity — OESOPHAGUS

Explore this box plot interactively →