Negative regulation of axonogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of axonogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KBTBD6, PFAS, and TGFBI, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of axonogenesis activity versus KBTBD6 in LARGE_INTESTINE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KBTBD6 →	-0.626	-0.261	<.001	<.001	3	8
PANCREAS	PFAS →	-1.202	-0.432	<.001	<.001	3	8
SOFT_TISSUE	TGFBI →	+5.090	+0.326	.001	<.001	3	7
LARGE_INTESTINE	SDC4 →	+1.366	+0.194	<.001	.009	3	7
LUNG_NSCLC_LUAD	B3GNT3 →	+2.288	+0.243	<.001	<.001	3	7
LUNG_NSCLC_LUAD	CYB561 →	+0.971	+0.219	.006	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050771 vs KBTBD6 — LARGE_INTESTINE

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