Positive regulation of neurogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of neurogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, COL5A1, and SERPINF1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neurogenesis activity versus TIMP2 in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.621	+0.019	<.001	<.001	3	9
LSCC	COL5A1 →	+0.551	+0.035	<.001	<.001	3	8
CCRCC	SERPINF1 →	+0.788	+0.033	<.001	<.001	3	8
BRCA	TUBB6 →	+0.534	+0.026	<.001	<.001	3	8
CCRCC	EFEMP1 →	+1.029	+0.028	<.001	.001	3	8
BRCA	HSPA12B →	+0.448	+0.018	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050769 vs TIMP2 — BRCA

Explore this scatter interactively →