Positive regulation of neurogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of neurogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLIPR1, MICAL3, and PROCR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLIPR1 grouped by Positive regulation of neurogenesis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GLIPR1 →	-2.568	-0.190	<.001	.005	3	4
LUNG_NSCLC_LUSC	MICAL3 →	-0.923	-0.220	.006	.003	3	4
BONE	PROCR →	-1.994	-0.272	<.001	.003	3	4
BONE	ATAT1 →	+1.113	+0.267	.004	.003	3	4
BONE	SGSM2 →	+1.337	+0.237	.001	.004	3	4
BONE	ZKSCAN8 →	+0.917	+0.286	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLIPR1 by Positive regulation of neurogenesis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →