Negative regulation of phagocytosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR2A, PIK3R5, and MYO1F, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phagocytosis activity versus FCGR2A in OV (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FCGR2A →	+1.044	+0.230	<.001	<.001	3	8
BRCA	PIK3R5 →	+0.662	+0.147	<.001	<.001	3	7
BRCA	MYO1F →	+0.779	+0.143	<.001	<.001	3	7
GBM	C1orf162 →	+0.905	+0.203	<.001	<.001	3	7
BRCA	SERPING1 →	+0.948	+0.117	<.001	.002	3	7
LSCC	LILRB3 →	+0.615	+0.180	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050765 vs FCGR2A — OV

Explore this scatter interactively →