Negative regulation of phagocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIEN1, DDX54, and PPP2R5D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIEN1 grouped by Negative regulation of phagocytosis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	MIEN1 →	-0.499	-0.590	.001	.008	3	4
BLOOD_Lymphoma	DDX54 →	+0.496	+0.385	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	PPP2R5D →	+1.011	+0.195	.001	.006	3	3
OESOPHAGUS	CRADD →	-0.568	-0.277	<.001	<.001	3	3
OESOPHAGUS	ZMYM1 →	+0.955	+0.324	.002	.002	3	3
OESOPHAGUS	DEPDC1 →	+1.159	+0.321	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIEN1 by Negative regulation of phagocytosis activity — KIDNEY

Explore this box plot interactively →