Negative regulation of phagocytosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARS1, CPTP, and RRAGD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phagocytosis activity versus MARS1 in SKIN (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MARS1 →	-0.727	-0.205	<.001	<.001	3	4
SKIN	CPTP →	+0.985	+0.251	.003	.006	3	4
SKIN	RRAGD →	+1.457	+0.169	.009	.003	3	4
LUNG_NSCLC_LUAD	CD47 →	+1.549	+0.217	<.001	<.001	2	5
BLOOD_Lymphoma	TGFBRAP1 →	+0.666	+0.191	.005	.004	3	4
LARGE_INTESTINE	MRPL3 →	+0.525	+0.231	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050765 vs MARS1 — SKIN

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