Regulation of phagocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, MEFV, and IL4I1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phagocytosis activity versus CSF2RB in SKCM (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CSF2RB →	+2.144	+0.072	<.001	<.001	3	34
LAML	MEFV →	+2.528	+0.082	<.001	<.001	3	34
SKCM	IL4I1 →	+2.313	+0.064	<.001	<.001	3	34
SKCM	LILRB1 →	+2.068	+0.071	<.001	<.001	3	34
LAML	CLEC4A →	+2.149	+0.078	<.001	<.001	3	34
BLCA	SRGN →	+2.362	+0.065	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050764 vs CSF2RB — SKCM

Explore this scatter interactively →