Regulation of phagocytosis

Across TCGA patient cohorts, RNA activity of the Regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYTH4, ADGRE2, and PIK3R5, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phagocytosis activity versus CYTH4 in HNSC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+1.104	+0.277	<.001	<.001	3	10
OV	ADGRE2 →	+0.877	+0.256	<.001	<.001	3	10
GBM	PIK3R5 →	+1.014	+0.231	<.001	<.001	3	10
OV	MYO1F →	+0.901	+0.218	<.001	.001	3	10
OV	WAS →	+0.951	+0.236	<.001	.001	3	10
GBM	LILRB3 →	+0.847	+0.225	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050764 vs CYTH4 — HNSC

Explore this scatter interactively →