Regulation of phagocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of phagocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABR, SMAD7, and PPP4C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABR grouped by Regulation of phagocytosis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ABR →	-0.278	-0.139	.009	.001	3	6
SOFT_TISSUE	SMAD7 →	-0.147	-0.083	.002	.005	3	5
BONE	PPP4C →	-0.270	-0.100	.006	.007	3	5
BONE	WNT1 →	-0.190	-0.142	.008	<.001	3	4
LUNG_NSCLC_LUAD	BCAT1 →	+0.150	+0.107	.004	<.001	3	4
OVARY	PPARGC1A →	-0.264	-0.081	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABR by Regulation of phagocytosis activity — SOFT_TISSUE

Explore this box plot interactively →