Regulation of phagocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX2, SBK1, and ILF2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phagocytosis activity versus CBX2 in LUNG_NSCLC_LUSC (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CBX2 →	-2.697	-0.140	<.001	.002	3	12
BONE	SBK1 →	-2.417	-0.121	.001	.001	3	12
BREAST	ILF2 →	-0.909	-0.101	.007	.003	3	12
LUNG_NSCLC_LUSC	MVP →	+3.021	+0.153	<.001	<.001	3	11
BLOOD_Leukemia	CD68 →	+3.057	+0.093	<.001	<.001	3	11
LUNG_NSCLC_LUSC	OPTN →	+2.048	+0.123	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050764 vs CBX2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →