Regulation of phagocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY6G5C, SVIL, and POPDC3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phagocytosis activity versus LY6G5C in LUNG_SCLC (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LY6G5C →	-0.882	-0.195	<.001	<.001	3	7
LUNG_NSCLC_LUSC	SVIL →	+1.802	+0.248	<.001	<.001	3	6
BREAST	POPDC3 →	+2.011	+0.218	.006	.004	3	5
BREAST	APOL6 →	+1.950	+0.210	.001	<.001	3	5
LUNG_NSCLC_LUSC	SYTL4 →	+2.253	+0.204	.003	.005	3	4
LUNG_NSCLC_LUSC	GLS2 →	-1.960	-0.228	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050764 vs LY6G5C — LUNG_SCLC

Explore this scatter interactively →