Negative regulation of lipoprotein metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6V, POSTN, and NEXN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipoprotein metabolic process activity versus RNU6V in COAD (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6V →	+0.577	+0.114	.003	.001	3	4
COAD	POSTN →	+1.373	+0.102	.002	.006	3	4
BRCA	NEXN →	+0.619	+0.080	<.001	<.001	3	4
BRCA	LINC01929 →	+0.625	+0.081	.001	<.001	3	4
BRCA	SLC2A3 →	+0.826	+0.149	<.001	<.001	3	4
GBM	RN7SL670P →	-0.267	-0.112	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050748 vs RNU6V — COAD

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