Negative regulation of lipoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOC, PERM1, and TXNDC15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHOC grouped by Negative regulation of lipoprotein metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RHOC →	+1.151	+1.389	.002	<.001	3	7
BONE	PERM1 →	+0.880	+1.715	<.001	.006	3	7
URINARY_TRACT	TXNDC15 →	+1.660	+2.628	<.001	<.001	3	7
LUNG_NSCLC_LUSC	LATS2 →	+1.469	+1.890	.008	.001	3	7
LUNG_NSCLC_LUSC	PRAF2 →	+1.887	+2.260	<.001	<.001	3	7
LUNG_NSCLC_LUSC	CD99L2 →	+2.316	+1.971	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHOC by Negative regulation of lipoprotein metabolic process activity — CNS

Explore this box plot interactively →