Negative regulation of lipoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX17, EP300, and NFAT5, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipoprotein metabolic process activity versus DDX17 in SKIN (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DDX17 →	+0.606	+0.273	<.001	<.001	3	1
SKIN	EP300 →	+1.267	+0.332	.001	.002	3	1
SKIN	NFAT5 →	+1.008	+0.273	<.001	<.001	3	1
SKIN	WFDC1 →	-5.234	-0.322	.008	<.001	3	1
SKIN	IQCH →	+0.457	+0.206	.003	.004	3	1
SKIN	IDS →	+1.299	+0.235	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050748 vs DDX17 — SKIN

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