Regulation of lipoprotein metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRGV6, FGF12-AS1, and PRSS23, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipoprotein metabolic process activity versus TRGV6 in BRCA (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRGV6 →	-0.313	-0.419	.005	.008	3	3
GBM	FGF12-AS1 →	-0.786	-0.337	.001	.001	3	3
UCEC	PRSS23 →	+0.655	+0.474	<.001	<.001	3	3
OV	SNORD113-1 →	+0.313	+0.859	.006	.005	3	3
BRCA	C9orf153 →	-0.081	-0.489	.004	.002	3	2
OV	RPS10P14 →	-0.348	-0.587	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050746 vs TRGV6 — BRCA

Explore this scatter interactively →