Regulation of lipoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTA1, TNS2, and ANAPC13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNTA1 grouped by Regulation of lipoprotein metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SNTA1 →	+1.066	+0.600	.001	.006	3	5
CNS	TNS2 →	+1.985	+1.051	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ANAPC13 →	+0.363	+0.429	.002	.002	3	4
LUNG_NSCLC_LUAD	DNAJC1 →	+0.907	+0.364	.001	.005	3	4
BREAST	MPC2 →	+0.934	+0.763	<.001	.005	3	4
PANCREAS	TXNDC15 →	+0.887	+1.387	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNTA1 by Regulation of lipoprotein metabolic process activity — BREAST

Explore this box plot interactively →