Regulation of lipoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ULK1, RB1CC1, and PCMTD1, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipoprotein metabolic process activity versus ULK1 in LUNG_NSCLC_LUSC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ULK1 →	+1.512	+0.141	.005	<.001	2	15
LUNG_NSCLC_LUSC	RB1CC1 →	+1.432	+0.171	.003	<.001	3	14
URINARY_TRACT	PCMTD1 →	+1.085	+0.105	.005	.007	3	12
LUNG_NSCLC_LUSC	SH3BP5L →	+0.851	+0.133	.002	<.001	3	11
LUNG_NSCLC_LUSC	PLEKHM3 →	+0.710	+0.113	.002	<.001	3	11
LUNG_NSCLC_LUSC	XRN1 →	+0.858	+0.117	.005	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050746 vs ULK1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →