Regulation of lipoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of lipoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1522, RAVER2, and POLR1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipoprotein metabolic process activity versus KIAA1522 in LUNG_NSCLC_LUAD (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KIAA1522 →	+1.026	+0.673	.002	.002	3	5
BONE	RAVER2 →	-1.977	-1.476	.002	<.001	3	5
BONE	POLR1B →	-0.991	-1.444	.004	.002	3	5
SOFT_TISSUE	CELSR1 →	+2.342	+1.586	.001	<.001	3	5
URINARY_TRACT	NCR3LG1 →	-1.932	-1.331	.003	.004	3	4
SOFT_TISSUE	TBC1D24 →	-1.237	-1.697	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050746 vs KIAA1522 — LUNG_NSCLC_LUAD

Explore this scatter interactively →