Positive regulation of peptidyl-tyrosine phosphorylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCRL2, GPR174, and SEPTIN6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidyl-tyrosine phosphorylation activity versus CCRL2 in LSCC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCRL2 →	+0.704	+0.263	.001	.003	3	5
LSCC	GPR174 →	+0.859	+0.235	<.001	<.001	3	5
LSCC	SEPTIN6 →	+0.490	+0.209	.002	<.001	3	5
HNSC	IRF1 →	+0.538	+0.187	.009	<.001	3	5
HNSC	BCL2A1 →	+1.000	+0.242	.001	<.001	3	5
HNSC	CCR1 →	+0.753	+0.235	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050731 vs CCRL2 — LSCC

Explore this scatter interactively →