Positive regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACCS, DTX4, and FOXO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACCS grouped by Positive regulation of peptidyl-tyrosine phosphorylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACCS →	-1.370	-1.033	<.001	<.001	3	5
SOFT_TISSUE	DTX4 →	+2.008	+1.406	.008	<.001	3	4
SOFT_TISSUE	FOXO3 →	+1.517	+1.361	<.001	<.001	3	4
SOFT_TISSUE	BMT2 →	+1.080	+1.213	<.001	.007	3	4
LUNG_NSCLC_LUAD	MTM1 →	+0.725	+0.717	<.001	.001	3	4
OESOPHAGUS	PDE6D →	+0.788	+1.330	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACCS by Positive regulation of peptidyl-tyrosine phosphorylation activity — BREAST

Explore this box plot interactively →