Positive regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF549, DDX5, and STX6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidyl-tyrosine phosphorylation activity versus ZNF549 in LIVER (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF549 →	-2.037	-1.628	<.001	<.001	3	4
LIVER	DDX5 →	-0.564	-1.526	.004	<.001	3	3
LIVER	STX6 →	-0.712	-1.526	<.001	<.001	3	3
BLOOD_Myeloma	DDX42 →	-0.970	-1.823	.006	<.001	3	3
BLOOD_Myeloma	MAPK8 →	-1.142	-1.809	.001	<.001	3	3
BLOOD_Myeloma	LNPEP →	-1.047	-1.779	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050731 vs ZNF549 — LIVER

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