Regulation of peptidyl-tyrosine phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, AIF1, and THEMIS2_T593, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-tyrosine phosphorylation activity versus WIPF1 in OV (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.472	+0.038	.004	.001	3	9
GBM	AIF1 →	+0.832	+0.055	<.001	<.001	3	9
LSCC	THEMIS2_T593 →	+0.838	+0.043	<.001	<.001	3	9
GBM	TNFAIP8L2 →	+0.670	+0.038	<.001	<.001	3	9
LSCC	ADA2 →	+0.462	+0.029	<.001	<.001	3	9
OV	MPP1 →	+0.443	+0.032	.002	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050730 vs WIPF1 — OV

Explore this scatter interactively →