Regulation of peptidyl-tyrosine phosphorylation

Across TCGA patient cohorts, RNA activity of the Regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAJ27, MTND4LP14, and NIPAL2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-tyrosine phosphorylation activity versus TRAJ27 in COAD (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ27 →	+0.562	+0.192	.002	.004	3	2
OV	MTND4LP14 →	-1.096	-0.208	.007	.004	3	2
COAD	NIPAL2 →	-0.591	-0.212	.003	.004	3	1
COAD	KRT17P1 →	+0.058	+0.187	<.001	.002	3	1
COAD	G6PC3 →	-0.419	-0.166	.002	.004	3	1
COAD	PDSS1 →	-0.485	-0.195	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050730 vs TRAJ27 — COAD

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