Regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF33, PTPN1, and SLC16A6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF33 grouped by Regulation of peptidyl-tyrosine phosphorylation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARHGEF33 →	-0.165	-0.144	.003	<.001	3	6
SKIN	PTPN1 →	-0.202	-0.185	<.001	<.001	3	6
CNS	SLC16A6 →	-0.185	-0.115	.003	.001	3	5
LUNG_NSCLC_LUAD	PPP5C →	-0.227	-0.133	<.001	<.001	3	5
LUNG_SCLC	SDF4 →	+0.432	+0.138	<.001	<.001	3	5
PANCREAS	TARBP2 →	-0.255	-0.165	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF33 by Regulation of peptidyl-tyrosine phosphorylation activity — LUNG_SCLC

Explore this box plot interactively →