Regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNLS, SH3GLB2, and ZNF823, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNLS grouped by Regulation of peptidyl-tyrosine phosphorylation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNLS →	+1.605	+0.774	.001	.002	3	4
LUNG_NSCLC_LUAD	SH3GLB2 →	+0.457	+0.376	.008	.009	3	4
LUNG_NSCLC_LUAD	ZNF823 →	+0.469	+0.417	.002	.003	3	4
LARGE_INTESTINE	COX19 →	+0.662	+0.200	.007	.005	3	4
LUNG_NSCLC_LUAD	SRSF8 →	+0.593	+0.579	.005	.005	2	5
URINARY_TRACT	SPRY4 →	-1.581	-0.324	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNLS by Regulation of peptidyl-tyrosine phosphorylation activity — OVARY

Explore this box plot interactively →