Regulation of peptidyl-tyrosine phosphorylation

Across TCGA cell cohorts, RNA activity of the Regulation of peptidyl-tyrosine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, WNT10A, and ITGB4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of peptidyl-tyrosine phosphorylation activity versus GPRC5A in OVARY (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPRC5A →	+3.812	+1.547	<.001	<.001	3	6
LUNG_NSCLC_LUAD	WNT10A →	+1.566	+0.930	.002	<.001	3	6
URINARY_TRACT	ITGB4 →	+6.625	+1.976	<.001	<.001	3	5
STOMACH	TBC1D16 →	-0.859	-1.566	.002	.001	3	5
BLOOD_Leukemia	ADAM9 →	+0.815	+0.707	<.001	.004	3	5
LUNG_NSCLC_LUAD	KCNK6 →	+1.153	+1.085	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050730 vs GPRC5A — OVARY

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