Positive regulation of protein secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein secretion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_S67, RPL12_S38, and RPL5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein secretion activity versus NCL_S67 in UCEC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCL_S67 →	-0.870	-0.041	<.001	.001	3	9
LSCC	RPL12_S38 →	-0.677	-0.026	<.001	<.001	3	8
BRCA	RPL5 →	-0.231	-0.029	<.001	<.001	3	8
HNSC	SEPTIN4_S432 →	+0.643	+0.029	.001	.004	3	8
BRCA	SEPTIN8 →	+0.289	+0.022	<.001	<.001	3	8
BRCA	SORBS3 →	+0.331	+0.021	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050714 vs NCL_S67 — UCEC

Explore this scatter interactively →