Positive regulation of protein secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDC3, FEM1A, and ZNF232, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein secretion activity versus EDC3 in CNS (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EDC3 →	+0.712	+0.216	.001	<.001	3	5
LARGE_INTESTINE	FEM1A →	+0.418	+0.140	.009	.003	3	5
BLOOD_Leukemia	ZNF232 →	+1.174	+0.164	<.001	<.001	3	5
BLOOD_Leukemia	THEMIS2 →	-1.412	-0.159	.003	.001	3	5
LUNG_SCLC	RAB33B →	+0.649	+0.215	.003	.007	3	5
BLOOD_Leukemia	FEM1C →	+0.584	+0.139	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050714 vs EDC3 — CNS

Explore this scatter interactively →