Negative regulation of protein secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein secretion pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KPNA2, TNS1_S445, and CDK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein secretion activity versus KPNA2 in PDAC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KPNA2 →	-0.376	-0.032	.001	<.001	3	6
UCEC	TNS1_S445 →	+1.037	+0.024	.007	.003	3	5
UCEC	CDK2 →	-0.273	-0.030	.003	.003	3	5
CCRCC	SYTL4_S74 →	+0.639	+0.023	<.001	.003	3	5
OV	SEPTIN8 →	+0.338	+0.031	.003	.001	3	5
BRCA	C1orf198 →	+0.368	+0.020	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050709 vs KPNA2 — PDAC

Explore this scatter interactively →