Negative regulation of protein secretion

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BUB1, KIF2C, and MCM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein secretion activity versus BUB1 in BRCA (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BUB1 →	-0.950	-0.759	.001	<.001	3	6
BRCA	KIF2C →	-1.295	-0.870	<.001	<.001	3	6
GBM	MCM3 →	-0.406	-0.807	.003	.001	3	6
BRCA	MCM4 →	-0.623	-0.722	.001	<.001	3	5
GBM	EZH2 →	-0.689	-0.680	.001	.004	3	5
BRCA	FBXO5 →	-0.644	-0.669	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050709 vs BUB1 — BRCA

Explore this scatter interactively →