Negative regulation of protein secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPS8L1, PRRG4, and KCTD21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPS8L1 grouped by Negative regulation of protein secretion-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EPS8L1 →	+3.571	+1.082	<.001	.003	3	4
UPPER_AERODIGESTIVE_TRACT	PRRG4 →	+1.809	+1.223	.004	.001	3	4
LUNG_SCLC	KCTD21 →	+0.949	+0.295	.007	.005	3	4
UPPER_AERODIGESTIVE_TRACT	BICDL2 →	+2.666	+1.376	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CDC42BPG →	+1.690	+1.345	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	C15orf62 →	+1.012	+1.307	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPS8L1 by Negative regulation of protein secretion activity — OESOPHAGUS

Explore this box plot interactively →