Negative regulation of protein secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD44, PDLIM7, and SLC25A25, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein secretion activity versus CD44 in BONE (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CD44 →	-6.658	-0.345	<.001	.001	3	7
BONE	PDLIM7 →	-1.873	-0.404	<.001	.003	3	6
LUNG_SCLC	SLC25A25 →	+0.741	+0.192	.003	.001	3	6
BLOOD_Lymphoma	IL1RAP →	-2.469	-0.165	.003	<.001	3	5
BLOOD_Leukemia	ZYX →	-2.201	-0.177	.001	.001	3	5
LUNG_NSCLC_LUSC	TNFRSF10D →	-3.050	-0.297	.007	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050709 vs CD44 — BONE

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