Regulation of protein secretion

Across TCGA patient cohorts, RNA activity of the Regulation of protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACP3, SH2D1B, and NAT8B, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein secretion activity versus ACP3 in OV (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACP3 →	+1.821	+0.212	.001	<.001	3	2
COAD	SH2D1B →	+0.657	+0.200	.001	<.001	3	2
COAD	NAT8B →	+1.863	+0.168	.005	.002	3	2
COAD	MMP28 →	+1.415	+0.180	.001	.003	3	2
COAD	ADORA3 →	+0.866	+0.194	<.001	<.001	3	2
OV	STAM2 →	+0.713	+0.212	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050708 vs ACP3 — OV

Explore this scatter interactively →