Regulation of protein secretion

Across TCGA cell cohorts, RNA activity of the Regulation of protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTA1, EDARADD, and ENPP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNTA1 grouped by Regulation of protein secretion-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SNTA1 →	+1.566	+0.164	.008	.001	3	4
OESOPHAGUS	EDARADD →	-1.382	-0.141	.005	.009	3	4
LUNG_NSCLC_LUSC	ENPP1 →	+1.634	+0.183	.008	.007	3	3
SOFT_TISSUE	NR2F2 →	-2.231	-1.065	<.001	.006	3	3
LARGE_INTESTINE	NCAM2 →	+0.062	+0.103	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	ALDH1A3 →	+1.802	+0.123	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNTA1 by Regulation of protein secretion activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →