Regulation of defense response to virus by host

Across TCGA patient cohorts, RNA activity of the Regulation of defense response to virus by host pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP14, APOBEC3G, and GBP1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus by host activity versus PARP14 in DLBC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	PARP14 →	+1.742	+0.073	<.001	<.001	3	33
UCS	APOBEC3G →	+1.429	+0.035	<.001	.006	2	34
SKCM	GBP1 →	+1.746	+0.039	<.001	<.001	3	32
UCS	IRF1 →	+1.478	+0.056	<.001	<.001	3	32
UCS	NMI →	+1.076	+0.040	<.001	<.001	3	31
UCS	TRIM21 →	+1.067	+0.051	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050691 vs PARP14 — DLBC

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