Regulation of defense response to virus by host

Across TCGA patient cohorts, RNA activity of the Regulation of defense response to virus by host pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINB9, TRIM21, and LCP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus by host activity versus SERPINB9 in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SERPINB9 →	+0.527	+0.066	<.001	<.001	3	10
HNSC	TRIM21 →	+0.490	+0.056	<.001	<.001	3	10
GBM	LCP1 →	+0.841	+0.070	<.001	<.001	3	10
GBM	CYRIB →	+0.325	+0.051	<.001	<.001	3	10
GBM	DEF6 →	+0.619	+0.062	<.001	<.001	3	10
LSCC	DOCK10 →	+0.466	+0.070	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050691 vs SERPINB9 — LSCC

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