Regulation of defense response to virus by host

Across TCGA patient cohorts, RNA activity of the Regulation of defense response to virus by host pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SULT1C4, CASP5, and SCN4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus by host activity versus SULT1C4 in OV (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SULT1C4 →	-0.919	-0.110	<.001	<.001	3	6
COAD	CASP5 →	+0.972	+0.194	.002	.003	3	6
HNSC	SCN4B →	-0.842	-0.194	<.001	<.001	3	5
LSCC	ZDHHC4P1 →	+1.082	+0.251	<.001	<.001	3	5
GBM	DLG2 →	-0.509	-0.157	.003	<.001	3	5
BRCA	MAML3 →	-0.501	-0.165	.009	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050691 vs SULT1C4 — OV

Explore this scatter interactively →