Regulation of defense response to virus by host

Across TCGA cell cohorts, RNA activity of the Regulation of defense response to virus by host pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEC, SMIM8, and ANKIB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLEC grouped by Regulation of defense response to virus by host-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLEC →	-1.085	-0.244	.001	<.001	3	4
BLOOD_Leukemia	SMIM8 →	+0.684	+0.260	<.001	<.001	3	4
LIVER	ANKIB1 →	-0.785	-0.256	<.001	.004	2	4
SOFT_TISSUE	SEMA6C →	+1.462	+0.252	.003	.004	3	3
SKIN	MET →	-1.048	-0.245	.007	<.001	2	4
OESOPHAGUS	RHBDD1 →	+0.536	+0.246	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLEC by Regulation of defense response to virus by host activity — LARGE_INTESTINE

Explore this box plot interactively →