Regulation of defense response to virus by host

Across TCGA cell cohorts, RNA activity of the Regulation of defense response to virus by host pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOC6, CEP135, and CDC45, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus by host activity versus EXOC6 in STOMACH (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EXOC6 →	-1.309	-0.129	.001	.001	3	5
LARGE_INTESTINE	CEP135 →	-1.253	-0.183	<.001	.002	3	5
LARGE_INTESTINE	CDC45 →	-1.160	-0.172	<.001	.004	3	5
OESOPHAGUS	FANCA →	-0.968	-0.193	.001	.003	3	5
BLOOD_Lymphoma	MTMR12 →	-0.974	-0.132	.001	.009	3	5
LARGE_INTESTINE	ANKRD50 →	-0.991	-0.172	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050691 vs EXOC6 — STOMACH

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