Regulation of defense response to virus

Across TCGA patient cohorts, RNA activity of the Regulation of defense response to virus pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, DEF6, and SASH3_S97, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus activity versus ADPRH in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADPRH →	+0.511	+0.037	<.001	<.001	3	10
CCRCC	DEF6 →	+0.498	+0.052	<.001	<.001	3	9
BRCA	SASH3_S97 →	+0.769	+0.024	<.001	.001	3	9
LSCC	THEMIS2_T593 →	+0.668	+0.042	<.001	<.001	3	9
BRCA	UBA7 →	+0.446	+0.039	<.001	<.001	3	9
LSCC	ANKRD44 →	+0.406	+0.057	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050688 vs ADPRH — OV

Explore this scatter interactively →