Regulation of defense response to virus

Across TCGA patient cohorts, RNA activity of the Regulation of defense response to virus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGI1, ZKSCAN7-AS1, and TNIP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus activity versus MAGI1 in HNSC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAGI1 →	-0.586	-0.170	.001	<.001	3	6
BRCA	ZKSCAN7-AS1 →	-0.518	-0.170	<.001	.007	3	5
LSCC	TNIP3 →	+0.999	+0.151	<.001	.003	2	6
HNSC	EFNB3 →	-0.815	-0.167	<.001	<.001	3	5
CCRCC	FBXO6 →	+0.360	+0.110	<.001	.002	3	5
HNSC	STXBP1 →	-0.680	-0.126	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050688 vs MAGI1 — HNSC

Explore this scatter interactively →