Regulation of defense response to virus

Across TCGA cell cohorts, RNA activity of the Regulation of defense response to virus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCUB, QSER1, and SCAF4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of defense response to virus activity versus MCUB in BLOOD_Leukemia (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MCUB →	-1.385	-0.137	<.001	<.001	3	5
BLOOD_Leukemia	QSER1 →	-0.511	-0.111	.007	.006	2	6
LIVER	SCAF4 →	-0.888	-0.208	<.001	<.001	3	5
LIVER	KPNA5 →	-1.182	-0.224	.003	.002	3	5
LIVER	SMARCB1 →	-0.965	-0.187	.008	.001	3	5
PANCREAS	TSC1 →	-0.652	-0.127	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050688 vs MCUB — BLOOD_Leukemia

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