Negative regulation of defense response to virus

Across TCGA patient cohorts, RNA activity of the Negative regulation of defense response to virus pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1, CD74, and DOCK10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of defense response to virus activity versus SAMHD1 in COAD (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SAMHD1 →	+0.311	+0.023	.006	.002	3	7
COAD	CD74 →	+0.513	+0.026	<.001	<.001	3	7
BRCA	DOCK10 →	+0.403	+0.039	<.001	<.001	3	7
BRCA	LGALS9 →	+0.706	+0.047	<.001	<.001	3	7
BRCA	TRIM22 →	+0.399	+0.026	<.001	<.001	3	6
BRCA	HLA-DMA →	+0.531	+0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050687 vs SAMHD1 — COAD

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