Negative regulation of defense response to virus

Across TCGA patient cohorts, RNA activity of the Negative regulation of defense response to virus pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDHP46, ENPP7P7, and SNORA80B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of defense response to virus activity versus GAPDHP46 in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GAPDHP46 →	-0.446	-0.241	.003	.001	3	4
HNSC	ENPP7P7 →	-0.597	-0.354	<.001	<.001	3	3
GBM	SNORA80B →	-0.560	-0.180	.005	.003	3	3
LSCC	EDIL3 →	-0.702	-0.172	.005	<.001	3	3
HNSC	CHD6 →	-0.483	-0.209	.002	.004	2	4
HNSC	PKN3 →	-0.739	-0.242	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050687 vs GAPDHP46 — HNSC

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