Negative regulation of defense response to virus

Across TCGA cell cohorts, RNA activity of the Negative regulation of defense response to virus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL26, QPCT, and TMEM127, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of defense response to virus activity versus RPL26 in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPL26 →	+0.516	+0.117	<.001	.001	3	5
OVARY	QPCT →	-2.769	-0.190	.007	.003	3	5
BREAST	TMEM127 →	-0.734	-0.184	<.001	<.001	3	5
BREAST	RPL17 →	+1.061	+0.263	.001	<.001	3	5
BLOOD_Leukemia	AP3D1 →	-0.440	-0.104	<.001	.004	3	4
BLOOD_Leukemia	ADPRM →	+0.716	+0.142	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0050687 vs RPL26 — BLOOD_Leukemia

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